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Brand: Exbio

Anti-Hu CD38 PE-Cy (TM)7

$306.00

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Anti-Hu CD38 PE-Cy (TM)7

Anti-Hu CD38 PE-Cy (TM)7

Product name Anti-Hu CD38 PE-Cy (TM)7
Delivery condition Blue ice (+4°C)
Delivery lead time in business days 3-5 days if in stock; 3-5 weeks if production needed
Storage condition Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Brand ExBio
Host species Mouse
Isotype IgG1
Clonality Monoclonal Antibody
Immunogen Human thymocytes in foetus
Clone Name HIT2
Protein Name CD38
Format Liquid in stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

The mouse monoclonal antibody HIT2 reacts with an extracellular epitope of CD38, a 45 kDa type II transmembrane glycoprotein strongly expressed mainly on plasma cells and activated T and B lymphocytes; it is an antigenic marker of lymphoid cells. Its binding is blocked by daratumumab.

CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. Another role of CD38 is provided by enzymatic activity of its extracellular part. CD38 acts as NAD+ glycohydrolase converting NAD+ into ADP-ribose, as ADP-ribosyl cyclase producing cADPR and as cADPR hydrolase, thus affecting levels of calcium-mobilizing metabolites. ADPR produced by CD38 serves as an important second messenger of neutrophil and dendritic cell migration. CD38 belongs to markers of B cell subsets, leukemia, and a target of immunotherapy in myeloma treatment.

Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.

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