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View ProductsCD253 Recombinant Protein
| Size | 100ug |
|---|---|
| Brand | ProteoGenix |
| Product type | Recombinant Proteins |
| Host Species | Escherichia coli (E. coli) |
| Applications | Elisa, WB |
| Product name | CD253 Recombinant Protein |
|---|---|
| Uniprot ID | P50591 |
| Uniprot link | http://www.uniprot.org/uniprot/P50591 |
| Origin species | Homo sapiens (Human) |
| Expression system | Prokaryotic expression |
| Sequence | MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG |
| Molecular weight | 33.78kDa |
| Protein delivered with Tag? | C-terminal His Tag |
| Purity estimated | >90% by SDS-PAGE |
| Buffer | PBS pH7.5 |
| Delivery condition | Dry Ice |
| Storage condition | Store at - 20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. |
| Brand | ProteoGenix |
| Host species | Escherichia coli (E.coli) |
| Applications | ELISA,WB |
| Fragment Type | Met1~Gly281 |
| Aliases /Synonyms | APO2L, TRAIL |
| Reference | PX-P4111 |
| Note | For research use only |
Description of CD253 Recombinant Protein
General Information about CD253 Recombinant Protein
Recombinant human CD253 is a 19.6 kDa protein consisting of 168 amino acids, corresponding to the TNF homologous region of the human TRAIL / ApoL2 extracellular domain. TNF-induced ligand apoptosis (TRAIL) is expressed in many tissues including spleen, lung, and prostate and can induce apoptosis depending on specific tumors. Apoptosis begins with the combination of two death receptors DR4 and DR5, which trigger cell death through the Caspian cascade. However, there are two types of ornamental receptors DcR1 and DcR2 that competitively bind to CD253, but do not induce apoptosis. The possible use of TRAIL as a therapeutic anticancer agent has been confirmed in numerous studies, which have shown that about two thirds of the tumor cell lines tested have tumoricidal activity. Recombinant human CD253 is a rabbit immunogen used to produce anti-human CD253.
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