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Brand: ProteoGenix

Diphtheria toxin

Host species:
Escherichia coli (E.coli)
Uniprot ID:
P00587
Molecular weight:
76.35kDa

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Gly26–Ser560
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Diphtheria toxin

Diphtheria toxin

Product name Diphtheria toxin
Uniprot ID P00587
Uniprot link http://www.uniprot.org/uniprot/P00587
Expression system Prokaryotic expression
Sequence MKKIWLALAGLVLAFSASAKEASSYDYILGWEFGGGVPEHKKEENMLSHLYVSSKDKENISKENDDVLDEKEEEAEETEE EELEGADDVVDSSKSFVMENFSSYHGTKPGYVDSIQKGIQKPKSGTQGNYDDDWKEFYSTDNKYDAAGYSVDNENPLSGK AGGVVKVTYPGLTKVLALKVDNAETIKKELGLSLTEPLMEQVGTEEFIKRFGDGASRVVLSLPFAEGSSSVEYINNWEQA KALSVELEINFETRGKRGQDAMYEYMAQACAGNRVRRSVGSSLSCINLDWDVIRDKTKTKIESLKEHGPIKNKMSESPNK TVSEEKAKQYLEEFHQTALEHPELSELKTVTGTNPVFAGANYAAWAVNVAQVIDSETADNLEKTTAALSILPGIGSVMGI ADGAVHHNTEEIVAQSIALSSLMVAQAIPLVGELVDIGFAAYNFVESIINLFQVVHNSYNRPAYSPGHKTQPFLHDGYAV SWNTVEDSIIRTGFQGESGHDIKITAENTPLPIAGVLLPTIPGKLDVNKSKTHISVNGRKIRMRCRAIDGDVTFCRPKSP VYVGNGVHANLHVAFHRSSSEKIHSNEISSDSIGVLGYQKTVDHTKVNSKLSLFFEIKSKEASSYDYILGWEFGGGVPEH KKEENMLSHLYVSSKDKENISKENDDVLDEKEEEAEETEEEELEGSHHHHHH
Molecular weight 76.35kDa
Purity estimated >60% by SDS-PAGE
Buffer PBS, pH=7.5
Delivery condition Dry Ice
Delivery lead time in business days Europe: 5-7 working days
USA & Canada: 7-10 working days
Rest of the world: 5-12 working days
Storage condition 4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
Brand ProteoGenix
Host species Escherichia coli (E.coli)
Fragment Type Gly26-Ser560
Aliases /Synonyms NAD(+)--diphthamide ADP-ribosyltransferase
Reference PX-P4480
Note For research use only
Molecular Constructor
Gly26–Ser560
Product name Diphtheria toxin
Uniprot ID P00587
Uniprot link http://www.uniprot.org/uniprot/P00587
Expression system Prokaryotic expression
Sequence MKKIWLALAGLVLAFSASAKEASSYDYILGWEFGGGVPEHKKEENMLSHLYVSSKDKENISKENDDVLDEKEEEAEETEE EELEGADDVVDSSKSFVMENFSSYHGTKPGYVDSIQKGIQKPKSGTQGNYDDDWKEFYSTDNKYDAAGYSVDNENPLSGK AGGVVKVTYPGLTKVLALKVDNAETIKKELGLSLTEPLMEQVGTEEFIKRFGDGASRVVLSLPFAEGSSSVEYINNWEQA KALSVELEINFETRGKRGQDAMYEYMAQACAGNRVRRSVGSSLSCINLDWDVIRDKTKTKIESLKEHGPIKNKMSESPNK TVSEEKAKQYLEEFHQTALEHPELSELKTVTGTNPVFAGANYAAWAVNVAQVIDSETADNLEKTTAALSILPGIGSVMGI ADGAVHHNTEEIVAQSIALSSLMVAQAIPLVGELVDIGFAAYNFVESIINLFQVVHNSYNRPAYSPGHKTQPFLHDGYAV SWNTVEDSIIRTGFQGESGHDIKITAENTPLPIAGVLLPTIPGKLDVNKSKTHISVNGRKIRMRCRAIDGDVTFCRPKSP VYVGNGVHANLHVAFHRSSSEKIHSNEISSDSIGVLGYQKTVDHTKVNSKLSLFFEIKSKEASSYDYILGWEFGGGVPEH KKEENMLSHLYVSSKDKENISKENDDVLDEKEEEAEETEEEELEGSHHHHHH
Molecular weight 76.35kDa
Purity estimated >60% by SDS-PAGE
Buffer PBS, pH=7.5
Delivery condition Dry Ice
Delivery lead time in business days Europe: 5-7 working days
USA & Canada: 7-10 working days
Rest of the world: 5-12 working days
Storage condition 4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
Brand ProteoGenix
Host species Escherichia coli (E.coli)
Fragment Type Gly26-Ser560
Aliases /Synonyms NAD(+)--diphthamide ADP-ribosyltransferase
Reference PX-P4480
Note For research use only
Molecular Constructor
Gly26–Ser560

General Information about Diphtheria toxin

Diphtheria toxin is a complete toxin catalyst and protein synthesis inhibitor of ADP-ribosylation of EF-2. Diphtheria toxin from Corynebacterium diphtheriae can inhibit protein synthesis by catalyzing the ADP-ribosylation of eukaryotic aminoacyltransferase II (EF-2). Diphtheria toxin is cell permeable and can be transported across the endosomal membrane in response to low pH3. Diphtheria toxin is synthesized and excreted as an enzyme and must undergo two covalent changes to be activated

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