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ProteoGenix
Recombinant Proteins
Escherichia coli (E. coli)
Elisa, WB
Human Cav1 recombinant protein is a key component of the voltage-gated calcium channel family, which plays a crucial role in regulating calcium influx into cells. This protein is encoded by the CACNA1C gene and is commonly referred to as the Cav1.2 channel. It is highly expressed in the heart, brain, and smooth muscle cells, making it a potential drug target for various diseases. In this article, we will discuss the structure, activity, and application of human Cav1 recombinant protein as a drug target.
The human Cav1 recombinant protein consists of four subunits, each containing six transmembrane domains and a pore-forming region. These subunits come together to form a functional calcium channel, which allows the selective passage of calcium ions across the cell membrane. The alpha-1 subunit, encoded by the CACNA1C gene, is the largest and most important subunit of the Cav1.2 channel. It contains the voltage-sensing and pore-forming regions and is responsible for the channel’s overall function.
The main function of the Cav1.2 channel is to regulate the influx of calcium ions into cells. This influx is essential for a variety of cellular processes, including muscle contraction, hormone secretion, and neuronal signaling. The activity of the Cav1.2 channel is tightly regulated by various factors, including voltage, membrane potential, and intracellular signaling molecules. Any disruption in the activity of this channel can lead to pathological conditions, making it an attractive drug target.
The dysregulation of human Cav1 recombinant protein has been implicated in several diseases, making it a potential drug target for therapeutic intervention. For example, mutations in the CACNA1C gene have been linked to cardiac arrhythmias, which can lead to life-threatening conditions such as sudden cardiac death. Inhibition of the Cav1.2 channel has been shown to be effective in treating these arrhythmias, making it a promising target for anti-arrhythmic drugs.
Moreover, the overexpression of Cav1.2 channels has been observed in various types of cancer, including breast, prostate, and lung cancer. This overexpression has been linked to increased cell proliferation and survival, making it a potential target for cancer therapy. Inhibition of the Cav1.2 channel has been shown to reduce cancer cell growth and induce cell death, making it a promising target for anti-cancer drugs.
In addition, the Cav1.2 channel has also been implicated in neurological disorders such as bipolar disorder and schizophrenia. Studies have shown that mutations in the CACNA1C gene are associated with an increased risk of developing these disorders. Targeting the Cav1.2 channel with specific inhibitors has shown promising results in animal models, highlighting its potential as a drug target for these disorders.
In summary, human Cav1 recombinant protein is a key component of the voltage-gated calcium channel family and plays a crucial role in regulating calcium influx into cells. Its dysregulation has been linked to various diseases, making it a potential drug target for therapeutic intervention. With further research and development, inhibitors targeting the Cav1.2 channel could potentially be used in the treatment of cardiac arrhythmias, cancer, and neurological disorders.
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