Human Galectin-1 (GAL1) recombinant protein

General Information about Human Galectin-1 (GAL1) recombinant protein

Galectin-1 (Gal-1, GAL1) is a member of galectin Galectin is a type of animal lectin. Affinity and significant sequence similarity in carbohydrates. in the place. It is a homodimer with a molecular weight subunit of 14.5 kDa and each subunit contains six cysteine ​​residues. Cysteine ​​residues must be in the free state to maintain a molecular structure that can show readability. This endogenous lectin is widely expressed at the sites of inflammation and tumor growth and is considered an attractive immunosuppressant, which can restore tolerance and homeostasis of immune cells in autoimmune and inflammatory environments. On the other hand, galectin-1 contributes to different steps in tumor progression, including tumor cell adhesion, migration, and immune activation, indicating that galectin-1 blockade may generate benefits in the treatment of cancer. Cancer. Several potential glycoprotein ligands of galectin-1 have been identified, including lysosomal membrane glycoprotein and fibronectin, laminin, and CD43 and CD45 T-cell glycoprotein. Evidence shows that Gal-1 and its ligands are one of the main regulators of the immune response, such as T cell homeostasis and survival, T cell immune diseases, inflammation and allergies, and host interactions. -pathogen.