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100ug, 1MG
ProteoGenix
Primary Antibodies
Monoclonal Antibody
Mammalian cells
Elisa, WB
Pertuzumab is a recombinant humanized monoclonal antibody that targets the extracellular dimerization domain (subdomain II) of human epidermal growth factor receptor 2 protein (HER2). It was first used with docetaxel and another HER2-targeting monoclonal antibody trastuzumab to treat metastatic HER2-positive breast cancer. Since then, its indications have been expanded to be used as both neoadjuvant therapy and adjuvant therapy for the treatment of HER2-positive breast cancer with a high risk of recurrence.
Immobilized CD340 Recombinant Protein (cat. No. PX-P4121) at 0.5µg/mL (100µL/well) can bind Pertuzumab Biosimilar - Anti-ERBB2, EGFR2, CD340 mAb (cat. No. PX-TA1058) in indirect ELISA with Goat Anti-Human IgG secondary antibody coupled with HRP measured by OD450 giving an EC50 at 9.566M.
Pertuzumab Biosimilar - Anti-ERBB2, EGFR2, CD340 mAb, on SDS-PAGE under reducing and non-reducing condition. The gel was stained overnight with Coomassie Blue. The purity of the antibody is greater than 95%.
Publication
Rocha Tapia A, Abgottspon F, Nilvebrant J, Nygren P-Å, Duclos Ivetich S, Bello Hernandez AJ, et al. Site-directed Conjugation of Single-Stranded DNA to Affinity Proteins: Quantifying the Importance of Conjugation Strategy. ChemRxiv. 2023; doi:10.26434/chemrxiv-2023-hxx06
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