Recombinant Human VIRMA Protein, N-His

Description of Recombinant Human VIRMA Protein, N-His

Introduction

Recombinant Human VIRMA Protein, also known as KIAA1964, is a protein that is encoded by the Virm gene in humans. It is a 1,550 amino acid protein with a molecular weight of approximately 176 kDa. This protein plays a crucial role in epigenetic regulation and has been linked to various diseases, making it a promising target for therapeutic interventions.

Structure of Recombinant Human VIRMA Protein

The structure of Recombinant Human VIRMA Protein is composed of several functional domains, including a methyltransferase domain, a zinc finger domain, and a PHD finger domain. The methyltransferase domain is responsible for the catalytic activity of the protein, while the zinc finger and PHD finger domains are involved in DNA binding and protein-protein interactions, respectively.

The protein also contains multiple phosphorylation sites, which play a role in regulating its activity. Additionally, it has been found to form complexes with other proteins, such as the histone methyltransferase complex, which further modulates its function.

Activity of Recombinant Human VIRMA Protein

Recombinant Human VIRMA Protein is a histone methyltransferase, meaning it catalyzes the addition of methyl groups to specific amino acids on histone proteins. This activity is essential for the epigenetic regulation of gene expression, as it can alter the structure of chromatin and affect the accessibility of DNA to transcription factors.

Studies have shown that Recombinant Human VIRMA Protein primarily methylates histone H3 at lysine 36 (H3K36), a modification associated with transcriptional activation. It has also been found to methylate other histone proteins, such as H3K4 and H3K79, indicating its role in regulating multiple gene expression pathways.

Application of Recombinant Human VIRMA Protein

Due to its involvement in epigenetic regulation, Recombinant Human VIRMA Protein has been linked to various diseases, making it a potential therapeutic target. For instance, it has been found to play a role in the development and progression of cancer, as its overexpression has been observed in multiple cancer types.

Furthermore, studies have shown that Recombinant Human VIRMA Protein is essential for the maintenance of embryonic stem cells and the development of the central nervous system. Therefore, it has also been implicated in neurodegenerative disorders and developmental disorders, such as autism spectrum disorders.

The use of Recombinant Human VIRMA Protein as a diagnostic tool has also been explored. Its overexpression has been associated with poor prognosis in certain cancers, making it a potential biomarker for disease progression and treatment response.

Conclusion

In conclusion, Recombinant Human VIRMA Protein is a multifunctional protein that plays a crucial role in epigenetic regulation. Its structure, activity, and potential applications make it a promising target for therapeutic interventions and diagnostic purposes. Further research on this protein is needed to fully understand its role in various diseases and to develop effective treatments targeting its activity.