Introduction to Recombinant Mouse EDA2R Protein
Recombinant Mouse EDA2R Protein, also known as Tumor Necrosis Factor Receptor Superfamily Member 27 (TNFRSF27), is a protein that plays a crucial role in the immune system. It is a member of the TNF receptor superfamily and is involved in various cellular processes, including cell survival, proliferation, and differentiation. This protein is produced through recombinant DNA technology, making it a valuable tool for scientific research and potential therapeutic applications.
Structure of Recombinant Mouse EDA2R Protein
The recombinant Mouse EDA2R Protein is a 33 kDa protein composed of 295 amino acids. It is a type I transmembrane protein, meaning it has a cytoplasmic tail, a transmembrane region, and an extracellular domain. The extracellular domain is where the protein interacts with its ligands, such as the cytokine EDA-A1, to initiate signaling pathways. The cytoplasmic tail contains a death domain, which is essential for the activation of downstream signaling molecules.
In addition, the recombinant Mouse EDA2R Protein has two isoforms, EDA2R-1 and EDA2R-2, which differ in their cytoplasmic tails. These isoforms have distinct functions and are expressed in different tissues and cell types. EDA2R-1 is mainly expressed in immune cells, while EDA2R-2 is found in non-immune cells.
Activity of Recombinant Mouse EDA2R Protein
The main function of recombinant Mouse EDA2R Protein is to act as a receptor for the cytokine EDA-A1, also known as Tumor Necrosis Factor-Like Ligand 1A (TL1A). Upon binding to EDA-A1, the protein undergoes a conformational change, leading to the recruitment of adaptor proteins and the activation of downstream signaling pathways.
One of the major signaling pathways activated by recombinant Mouse EDA2R Protein is the nuclear factor-kappa B (NF-κB) pathway. This pathway plays a crucial role in regulating immune responses, cell survival, and inflammation. Activation of the NF-κB pathway by recombinant Mouse EDA2R Protein leads to the production of pro-inflammatory cytokines and chemokines, which recruit immune cells to the site of inflammation.
In addition, recombinant Mouse EDA2R Protein has been shown to promote the survival and proliferation of immune cells, such as T cells and B cells, through the activation of the Akt and ERK signaling pathways. This suggests that the protein plays a crucial role in maintaining immune homeostasis and regulating immune cell function.
Applications of Recombinant Mouse EDA2R Protein
The recombinant Mouse EDA2R Protein has various potential applications in scientific research and therapeutic interventions. One of the main uses of this protein is in studying the role of EDA-A1/EDA2R signaling in immune responses and inflammation. By using recombinant Mouse EDA2R Protein, researchers can manipulate the signaling pathway and study its effects on immune cells and inflammatory processes.
In addition, recombinant Mouse EDA2R Protein has been investigated as a potential therapeutic target for autoimmune diseases and cancer. As the protein is involved in regulating immune responses, targeting it could modulate the activity of immune cells and reduce inflammation in autoimmune diseases. Moreover, inhibiting the function of recombinant Mouse EDA2R Protein has been shown to suppress the growth and survival of cancer cells, making it a potential target for cancer treatment.
In conclusion, recombinant Mouse EDA2R Protein is a valuable tool for understanding the role of EDA-A1/EDA2R signaling in the immune system and its potential applications in disease treatment. Its structure, activity, and applications make it a
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