Recombinant Mouse IL31 Protein, N-His

Introduction to Recombinant Mouse IL31 Protein

Recombinant Mouse IL31 Protein, also known as Interleukin 31, is a cytokine that plays a crucial role in the immune system. It is a member of the IL-6 cytokine family and is primarily produced by activated T helper 2 (Th2) cells. This protein is involved in various biological processes, including inflammation, cell growth, and differentiation. Due to its important role in the immune system, Recombinant Mouse IL31 Protein has been extensively studied and is now widely used in scientific research and medical applications.

Structure of Recombinant Mouse IL31 Protein

Recombinant Mouse IL31 Protein is a 24-kDa protein consisting of 178 amino acids. It is a homodimer, meaning it is composed of two identical subunits. Each subunit contains four alpha-helices and a beta-sheet, which are arranged in a four-helix bundle. The structure of Recombinant Mouse IL31 Protein is similar to other members of the IL-6 cytokine family, such as IL-6 and IL-11.

The crystal structure of Recombinant Mouse IL31 Protein has been determined, revealing the exact arrangement of its amino acids and providing insights into its function. The structure also showed that Recombinant Mouse IL31 Protein has a high degree of similarity to human IL-31, with a sequence identity of 71%. This similarity allows for the use of Recombinant Mouse IL31 Protein in human studies and applications.

Activity of Recombinant Mouse IL31 Protein

Recombinant Mouse IL31 Protein is a potent activator of STAT3 signaling, a pathway involved in cell growth, survival, and differentiation. Upon binding to its receptor, IL31RA, Recombinant Mouse IL31 Protein triggers the phosphorylation of STAT3, leading to its activation and translocation into the nucleus. This results in the expression of genes involved in immune responses, inflammation, and tissue repair.

Recombinant Mouse IL31 Protein has been shown to have a variety of biological activities, including the induction of pro-inflammatory cytokines, chemokines, and growth factors. It also promotes the differentiation and activation of immune cells, such as macrophages, dendritic cells, and T cells. In addition, Recombinant Mouse IL31 Protein has been found to play a role in skin barrier function, as it can stimulate the production of antimicrobial peptides and promote wound healing.

Applications of Recombinant Mouse IL31 Protein

Recombinant Mouse IL31 Protein has a wide range of applications in scientific research and medical fields. It is commonly used in in vitro studies to investigate the role of IL31 in various biological processes, such as inflammation, immune responses, and tissue repair. Recombinant Mouse IL31 Protein has also been used in animal models to study its effects in vivo and to develop potential therapies for diseases associated with IL31 dysregulation, such as atopic dermatitis and allergic asthma.

In addition, Recombinant Mouse IL31 Protein has been utilized in the development of diagnostic tools, such as ELISA kits, for the detection and quantification of IL31 in biological samples. This allows for the monitoring of IL31 levels in patients with inflammatory or autoimmune diseases, providing valuable information for diagnosis and treatment.

Conclusion

In summary, Recombinant Mouse IL31 Protein is a crucial cytokine involved in various biological processes, including inflammation, cell growth, and differentiation. Its structure, activity, and applications have been extensively studied, making it a valuable tool in scientific research and a potential target for therapeutic interventions. With ongoing research and advancements in technology, Recombinant Mouse IL31 Protein continues to provide insights into the complex mechanisms of the immune system and offers promising prospects for the development of new treatments for immune-related diseases.