The Structure of Human ADGRE1/EMR1 HEK293T Stable Cell Line
The Human ADGRE1/EMR1 HEK293T Stable Cell Line is a genetically modified cell line derived from the Human Embryonic Kidney 293T (HEK293T) cell line. This cell line has been stably transfected with the gene encoding for the human ADGRE1/EMR1 protein, also known as EGF-like module-containing mucin-like hormone receptor 1.
The ADGRE1/EMR1 protein is a transmembrane glycoprotein that belongs to the EGF-TM7 family of adhesion G protein-coupled receptors. It is composed of a large extracellular domain containing multiple EGF-like repeats, a transmembrane domain, and a short cytoplasmic tail. This unique structure allows the ADGRE1/EMR1 protein to interact with various ligands and mediate signaling pathways involved in cell adhesion, migration, and immune response.
The Activity of Human ADGRE1/EMR1 HEK293T Stable Cell Line
The Human ADGRE1/EMR1 HEK293T Stable Cell Line is a valuable tool for studying the activity of the ADGRE1/EMR1 protein. The stable expression of ADGRE1/EMR1 in this cell line allows for the consistent and reliable production of the protein, making it ideal for functional assays and downstream applications.
One of the main activities of the ADGRE1/EMR1 protein is its role in immune response. It has been shown to be expressed on various immune cells, including macrophages, dendritic cells, and monocytes, and is involved in regulating immune cell activation and migration. The Human ADGRE1/EMR1 HEK293T Stable Cell Line can be used to study the interaction of the ADGRE1/EMR1 protein with immune cells and its role in immune response pathways.
Additionally, the ADGRE1/EMR1 protein has been implicated in cancer progression and metastasis. It has been shown to promote tumor growth and invasion by interacting with extracellular matrix proteins and promoting cell adhesion and migration. The Human ADGRE1/EMR1 HEK293T Stable Cell Line can be used to investigate the mechanisms of ADGRE1/EMR1-mediated cancer progression and to identify potential therapeutic targets.
Application of Human ADGRE1/EMR1 HEK293T Stable Cell Line
The Human ADGRE1/EMR1 HEK293T Stable Cell Line has a wide range of applications in both basic and translational research. One of its main applications is in drug discovery and development. The ADGRE1/EMR1 protein has been identified as a potential therapeutic target for various diseases, including cancer, autoimmune disorders, and inflammatory diseases. The Human ADGRE1/EMR1 HEK293T Stable Cell Line can be used in high-throughput screening assays to identify small molecule inhibitors or activators of the ADGRE1/EMR1 protein, which can then be further developed into potential drug candidates.
Another application of this cell line is in studying the role of ADGRE1/EMR1 in immune response and inflammation. By using flow cytometry, the Human ADGRE1/EMR1 HEK293T Stable Cell Line can be used to analyze the expression of the ADGRE1/EMR1 protein on immune cells and its role in immune cell activation and migration. This can provide valuable insights into the mechanisms of immune response and aid in the development of novel immunotherapies.
Furthermore, the Human ADGRE1/EMR1 HEK293T Stable Cell Line can be used in studies of cell adhesion and migration.
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