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ProteoGenix
Recombinant Proteins
Mammalian cells
Elisa, WB
Human eosinophil cationic protein (ECP) is a protein that is primarily secreted by activated eosinophils, a type of white blood cell involved in the body’s immune response. Eosinophils are known for their role in fighting parasitic infections and allergic reactions, but they also play a role in various inflammatory diseases. ECP is a highly basic protein with a molecular weight of approximately 16 kDa and is rich in arginine and lysine residues. In recent years, ECP has gained attention as a potential drug target due to its multifunctional properties and involvement in various diseases. In this article, we will explore the structure, activity, and potential applications of human ECP as a drug target.
ECP is a member of the ribonuclease A superfamily and shares structural similarities with other cationic proteins such as eosinophil-derived neurotoxin (EDN) and eosinophil-derived neurotoxin 2 (EDN2). The protein is composed of a single polypeptide chain with a characteristic three-dimensional structure consisting of an alpha-helical domain and a beta-sheet domain. The alpha-helical domain is responsible for the cationic charge of the protein, while the beta-sheet domain is involved in its ribonucleolytic activity.
ECP also contains a highly conserved active site, which is essential for its ribonucleolytic activity. This active site is composed of three amino acids: His-13, His-39, and His-41. These residues are responsible for the cleavage of RNA molecules, a process that is crucial for the protein’s antimicrobial and antiviral activity.
ECP has a wide range of biological activities, making it a promising drug target. Its main function is to protect the body against parasitic infections, but it also plays a role in various inflammatory conditions. ECP has been shown to have antimicrobial, antiviral, and immunomodulatory properties.
As an antimicrobial agent, ECP has been shown to be effective against a variety of microorganisms, including bacteria, fungi, and parasites. It exerts its antimicrobial activity by disrupting the cell membrane of these pathogens, leading to their death. Additionally, ECP has been found to have antiviral activity against several viruses, including HIV, influenza, and respiratory syncytial virus.
ECP also has immunomodulatory properties, meaning it can regulate the immune response. It has been shown to stimulate the production of cytokines, which are small proteins involved in the body’s immune response. This activity can be beneficial in conditions where the immune response is dysregulated, such as autoimmune diseases.
Due to its multifunctional properties, ECP has potential applications in various diseases. One of the most promising areas of research is the use of ECP as an antimicrobial agent. With the rise of antibiotic resistance, there is a growing need for alternative treatments for bacterial infections. ECP has shown promising results in preclinical studies as an effective antimicrobial agent, and further research is needed to explore its potential in clinical settings.
ECP also has potential applications in viral infections, particularly in the treatment of HIV. Studies have shown that ECP can inhibit the replication of HIV and reduce the viral load in infected cells. This makes it a promising candidate for the development of new antiviral therapies.
In addition to its antimicrobial and antiviral properties, ECP has also been studied for its potential in treating inflammatory diseases. Conditions such as asthma, chronic obstructive pulmonary disease (COPD), and inflammatory bowel disease (IBD) have been linked to increased levels of ECP. Thus, targeting ECP may be a potential therapeutic strategy for these diseases.
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