Human CD28 recombinant protein

Description of Human CD28 recombinant protein

General Information about Human CD28 recombinant protein

CD28 (Cluster of differentiation 28) is a disulfide-linked glycoprotein which belongs to the immunoglobulin (Ig) superfamily. It consists of a single Ig V-like extracellular domain, transmembrane domain and intracellular domain in the structure. composition. Mouse CD28 is structurally expressed on the surface of all parietal cells and is expressed by developing thymocytes into disulfide-bound homodimers or monomers. CD28 can bind to B7-1 and B7-2 ligands and together play an important role in T and B lymphocyte response. Members of the B7 / CD28 family can enhance or antagonize T cell receptor signal transduction and tolerance of peripheral cells according to central regulation. Thus, CD28 is involved in the activation of T cells, the induction of cell proliferation, the production of cytokines and the acceleration of T cell survival.