What are co-inhibitory receptors?

Co-inhibitory receptors are immune cell surface proteins that transmit signals limiting immune activation. They help prevent excessive immune responses and support immune tolerance.

What are co-stimulatory receptors?

Co-stimulatory receptors provide activating signals that support T cell proliferation, survival and effector functions after antigen recognition.

Which targets are commonly studied?

Frequently studied targets include PD-1, PD-L1, CTLA-4, LAG-3, TIGIT, TIM-3, CD28, CD80, CD86, ICOS, OX40 and 4-1BB.

Which reagent format should I choose?

Choose primary antibodies for detection, recombinant proteins for binding or assay development, research-grade biosimilars for reference studies and VHH antibodies when a compact binder format is preferred.

What should I check before ordering?

Check the target name, species reactivity, clone, host, isotype, format, application, product size, storage conditions and stock availability.

Which expression system is recommended for immune checkpoint proteins?

Many co-inhibitory and co-stimulatory receptors are glycoproteins that benefit from mammalian expression systems such as HEK293 or CHO cells. These systems help preserve native folding and post-translational modifications that are important for biological activity.

Can ProteoGenix support custom requirements?

Yes. For targets or formats not available as standard products, ProteoGenix can support custom antibody development, recombinant antibody production and related services.

Co-inhibitory & Co-stimulatory receptors

Validated Reagents for Reliable Immune Checkpoint Research

Explore our validated range of primary antibodies, research-grade biosimilars and VHH antibodies targeting key co-inhibitory and co-stimulatory receptors, with products ready to ship.

Save 20% on this selection. Use code ONCO20. Valid until September 15

Benmelstobart Biosimilar - Anti-B7-H1 mAb - Research Grade
- PX-TA1938
- Validated ELISA WB
Clonality:

Monoclonal Antibody

Isotype:

IgG1, kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $207.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Benmelstobart Biosimilar - Research Grade mAb
- PX-TA1938-d
- Validated ELISA WB
Clonality:

Monoclonal antibody

Isotype:

IgG1, kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $215.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Besufetamig Biosimilar - Research Grade
- PX-TA2449
- Validated WB
Clonality:

Monoclonal antibody

Host species:

Mammalian cells

Isotype:

IgG1, Kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $232.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Betifisolimab Biosimilar - Anti-CD274 mAb - Research Grade
- PX-TA1816
- Validated ELISA FC WB
Clonality:

Monoclonal Antibody

Isotype:

IgG1, kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $417.00.Current price is: $308.00.
+ 308 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Betifisolimab Biosimilar - Research Grade mAb
- PX-TA1816-d
- Validated ELISA WB
Clonality:

Monoclonal antibody

Isotype:

IgG1, kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $403.00.Current price is: $308.00.
+ 308 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Bintrafusp Biosimilar - Anti-CD274 mAb - Research Grade
- PX-TA1819
- Validated ELISA
Clonality:

Monoclonal Antibody

Isotype:

IgG1, lambda

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $218.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
BMS-936559/MDX-1105 Biosimilar - Anti-B7-H1 mAb - Research Grade
- PX-TA1916
Clonality:

Monoclonal Antibody

Isotype:

IgG4

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $203.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
BMS-936559/MDX-1105 Biosimilar - Research Grade mAb
- PX-TA1916-d
Clonality:

Monoclonal antibody

Isotype:

IgG4

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $203.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Botensilimab Biosimilar - Anti-CTLA4 mAb - Research Grade
- PX-TA1647
Clonality:

Monoclonal Antibody

Isotype:

IgG1, kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $217.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Brivestobart Biosimilar - Research Grade
- PX-TA2374
Clonality:

Monoclonal antibody

Host species:

Mammalian cells

Isotype:

IgG4, Kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $203.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Cadonilimab Biosimilar - Anti-PDCD1;CTLA4 mAb - Research Grade
- PX-TA1648
Clonality:

Monoclonal Antibody

Isotype:

Bispecific ,IgG1;Kappa;Lambda

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $212.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Cat CD274/PD-L1/B7-H1 Recombinant Protein, C-His
- ARO-P20925
Host species:

Mammalian cells

Origin species:

Cat

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $345.00.Current price is: $271.00.
+ 271 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Cat CD279/PDCD1/PD1 Recombinant Protein, C-His
- ARO-P20612
Host species:

Mammalian cells

Origin species:

Cat

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $326.00.Current price is: $271.00.
+ 271 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
CD152 / CTLA4, C-His, recombinant protein
- PX-P5569
Host species:

Mammalian cells

Origin species:

Homo sapiens (Human)

Brand:

ProteoGenix

Size:

100ug
$500.00
+ 500 loyalty points

In Stock Add to cart
CD223 / LAG3 Polyclonal Antibody
- PTX18515
- Validated WB
Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $180.00.Current price is: $140.00.
+ 140 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
CD223 / LAG3, C-His, recombinant protein
- PX-P5592
Host species:

Mammalian cells

Origin species:

Homo sapiens (Human)

Brand:

ProteoGenix

Size:

100ug
$500.00
+ 500 loyalty points

In Stock Add to cart

Co-inhibitory & Co-stimulatory Receptors

Researchers investigating immune regulation rely on co-inhibitory and co-stimulatory receptors to understand T cell activation, immune tolerance, cancer immunotherapy, autoimmune diseases, infectious diseases, and cell therapy development. Collectively, these molecules constitute the immune checkpoint pathways that regulate immune responses and have become central targets in immunology and immuno-oncology research.

ProteoGenix provides recombinant proteins and custom protein production services covering a broad range of immune checkpoint molecules and co-signaling receptors, supporting research from early discovery through preclinical development.

Representative Immune Checkpoint Targets

Immune checkpoint research encompasses a broad network of co-inhibitory and co-stimulatory receptors involved in regulating immune activation and tolerance. Below is a representative selection of targets available through ProteoGenix.

Frequently studied co-inhibitory receptors

Frequently studied co-stimulatory receptors

Can’t find your target?

Not all immune checkpoint molecules are commercially available in the format required for your study. Our scientists can design and produce custom recombinant proteins, antibodies, Fc-fusion constructs, tagged proteins and engineered variants tailored to your experimental needs.

Explore Custom Protein Production

Supporting Every Stage of Immune Checkpoint Research

Whether your objective is basic immunology research or therapeutic development, selecting the appropriate recombinant protein is essential for obtaining reliable experimental results.

Our products are routinely used for applications including:

- Receptor-ligand interaction studies
- Antibody screening and characterization
- ELISA development and validation
- Surface Plasmon Resonance (SPR)
- Bio-Layer Interferometry (BLI)
- Cell-based functional assays
- Flow cytometry assay development
- Biomarker validation
- Structural biology
- Immunotherapy target evaluation
- CAR-T and TCR research
- Drug discovery programs

FAQ

Many co-inhibitory and co-stimulatory receptors are glycoproteins that benefit from mammalian expression systems such as HEK293 or CHO cells. These systems help preserve native folding and post-translational modifications that are important for biological activity.

Trusted Worldwide

Why Researchers Trust ProteoGenix

From validated reagents for co-signaling receptor research to custom antibody development, recombinant production and technical support, ProteoGenix helps researchers move faster from target selection to reliable experimental results.

Scientific & Technical Support

Get expert support for product selection, format comparison, application fit and troubleshooting.
Quality Assurance

Work with documented reagents supported by QC processes and batch-specific information.
Custom Solutions

For specific targets or formats, ProteoGenix supports antibody development and recombinant production.
Global Delivery

Reliable cold-chain logistics worldwide with temperature-controlled shipping and tracking.

Co-inhibitory & Co-stimulatory receptors

Benmelstobart Biosimilar - Anti-B7-H1 mAb - Research Grade

Benmelstobart Biosimilar - Research Grade mAb

Besufetamig Biosimilar - Research Grade

Betifisolimab Biosimilar - Anti-CD274 mAb - Research Grade

Betifisolimab Biosimilar - Research Grade mAb

Bintrafusp Biosimilar - Anti-CD274 mAb - Research Grade

BMS-936559/MDX-1105 Biosimilar - Anti-B7-H1 mAb - Research Grade

BMS-936559/MDX-1105 Biosimilar - Research Grade mAb

Botensilimab Biosimilar - Anti-CTLA4 mAb - Research Grade

Brivestobart Biosimilar - Research Grade

Cadonilimab Biosimilar - Anti-PDCD1;CTLA4 mAb - Research Grade

Cat CD274/PD-L1/B7-H1 Recombinant Protein, C-His

Cat CD279/PDCD1/PD1 Recombinant Protein, C-His

CD152 / CTLA4, C-His, recombinant protein

CD223 / LAG3 Polyclonal Antibody

CD223 / LAG3, C-His, recombinant protein

Top Products

Anti-Human TREM2 VHH (SAA1136)

Anti-Human CD354/TREM1 (PY159)

Anti-Mouse CD283/TLR3 Polyclonal Antibody

Human CD274/PD-L1/B7-H1 Monoclonal Antibody 2.7A4

Representative Immune Checkpoint Targets

Frequently studied co-inhibitory receptors

Frequently studied co-stimulatory receptors

Can’t find your target?

Supporting Every Stage of Immune Checkpoint Research

FAQ

Why Researchers Trust ProteoGenix

Scientific & Technical Support

Quality Assurance

Custom Solutions

Global Delivery

Need a quote or more information? Contact us!

Cart (0 Items)