What are co-inhibitory receptors?

Co-inhibitory receptors are immune cell surface proteins that transmit signals limiting immune activation. They help prevent excessive immune responses and support immune tolerance.

What are co-stimulatory receptors?

Co-stimulatory receptors provide activating signals that support T cell proliferation, survival and effector functions after antigen recognition.

Which targets are commonly studied?

Frequently studied targets include PD-1, PD-L1, CTLA-4, LAG-3, TIGIT, TIM-3, CD28, CD80, CD86, ICOS, OX40 and 4-1BB.

Which reagent format should I choose?

Choose primary antibodies for detection, recombinant proteins for binding or assay development, research-grade biosimilars for reference studies and VHH antibodies when a compact binder format is preferred.

What should I check before ordering?

Check the target name, species reactivity, clone, host, isotype, format, application, product size, storage conditions and stock availability.

Which expression system is recommended for immune checkpoint proteins?

Many co-inhibitory and co-stimulatory receptors are glycoproteins that benefit from mammalian expression systems such as HEK293 or CHO cells. These systems help preserve native folding and post-translational modifications that are important for biological activity.

Can ProteoGenix support custom requirements?

Yes. For targets or formats not available as standard products, ProteoGenix can support custom antibody development, recombinant antibody production and related services.

Co-inhibitory & Co-stimulatory receptors

Validated Reagents for Reliable Immune Checkpoint Research

Explore our validated range of primary antibodies, research-grade biosimilars and VHH antibodies targeting key co-inhibitory and co-stimulatory receptors, with products ready to ship.

Save 20% on this selection. Use code ONCO20. Valid until September 15

Sudubrilimab Biosimilar - Research Grade mAb
- PX-TA1717-d
Clonality:

Monoclonal antibody

Isotype:

IgG1, kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $208.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Tamgiblimab Biosimilar - Anti-TIGIT mAb - Research Grade
- PX-TA1768
Clonality:

Monoclonal Antibody

Isotype:

IgG4, Kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $233.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Tazlestobart Biosimilar - Anti-CD152 mAb - Research Grade
- PX-TA2216
- Validated ELISA
Clonality:

Monoclonal Antibody

Isotype:

IgG1, kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $209.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Tebotelimab Biosimilar - Anti-PDCD1;LAG3 mAb - Research Grade
- PX-TA1722
Clonality:

Monoclonal Antibody

Isotype:

Bispecific scFv ,IgG4;Kappa;Kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $209.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Tiragolumab Biosimilar - Anti-TIGIT, VSIG9, VSTM3 mAb - Research Grade
- PX-TA1487
- Validated ELISA FC
Isotype:

IgG1, kappa

Brand:

ProteoGenix

Size:

100ug, 10mg, 1MG, 25mg, 50ug
Original price was: $133.00.Current price is: $100.00.
+ 100 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Tobemstomig Biosimilar - Anti-PD1 and LAG3 mAb - Research Grade
- PX-TA2074
Clonality:

Monoclonal Antibody

Isotype:

IgG1, kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $208.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Tremelimumab Biosimilar - Anti-CTLA4, CD152 mAb - Research Grade
- PX-TA1177
- Validated ELISA
Isotype:

IgG2, Kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $232.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Tupaia chinensis CD152/CTLA4 Recombinant Protein, N-His
- ARO-P18410
Host species:

Escherichia coli (E.coli)

Origin species:

Tupaia chinensis

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $339.00.Current price is: $271.00.
+ 271 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Tupaia chinensis CD274/PD-L1/B7-H1 Recombinant Protein, N-His
- ARO-P18418
Host species:

Escherichia coli (E.coli)

Origin species:

Tupaia chinensis

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $350.00.Current price is: $271.00.
+ 271 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Tuparstobart Biosimilar - Anti-FDC mAb - Research Grade
- PX-TA2091
- Validated ELISA WB
Clonality:

Monoclonal Antibody

Isotype:

IgG1, kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $232.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Tuvonralimab Biosimilar - Anti-CTLA4 mAb - Research Grade
- PX-TA1781
- Validated ELISA
Clonality:

Monoclonal Antibody

Isotype:

IgG1, kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $370.00.Current price is: $308.00.
+ 308 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Vibostolimab Biosimilar - Anti-TIGIT, VSIG9, VSTM3 mAb - Research Grade
- PX-TA1610
- Validated ELISA
Clonality:

Monoclonal Antibody

Isotype:

IgG1, kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $200.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Vilastobart Biosimilar - Anti-CD152 mAb - Research Grade
- PX-TA2149
- Validated ELISA WB
Clonality:

Monoclonal Antibody

Isotype:

IgG1-fused prodomain kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $233.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Volrustomig Biosimilar - Anti-PD1 and CTLA4 mAb - Research Grade
- PX-TA2077
- Validated ELISA WB
Clonality:

Monoclonal Antibody

Isotype:

IgG1-kappa/kappa-lambda

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $217.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Vudalimab Biosimilar - Anti-CTLA4;PDCD1 mAb - Research Grade
- PX-TA1739
Clonality:

Monoclonal Antibody

Isotype:

Bispecific ,IgG1,Kappa;Kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $224.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Xirestomig Biosimilar - Anti-Tumor necrosis factor receptor superfamily member 9; CD274 mAb - Research Grade
- PX-TA2151
- Validated ELISA WB
Clonality:

Monoclonal Antibody

Isotype:

IgG1-scFv_L2 dimer

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $208.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page

Co-inhibitory & Co-stimulatory Receptors

Researchers investigating immune regulation rely on co-inhibitory and co-stimulatory receptors to understand T cell activation, immune tolerance, cancer immunotherapy, autoimmune diseases, infectious diseases, and cell therapy development. Collectively, these molecules constitute the immune checkpoint pathways that regulate immune responses and have become central targets in immunology and immuno-oncology research.

ProteoGenix provides recombinant proteins and custom protein production services covering a broad range of immune checkpoint molecules and co-signaling receptors, supporting research from early discovery through preclinical development.

Representative Immune Checkpoint Targets

Immune checkpoint research encompasses a broad network of co-inhibitory and co-stimulatory receptors involved in regulating immune activation and tolerance. Below is a representative selection of targets available through ProteoGenix.

Frequently studied co-inhibitory receptors

Frequently studied co-stimulatory receptors

Can’t find your target?

Not all immune checkpoint molecules are commercially available in the format required for your study. Our scientists can design and produce custom recombinant proteins, antibodies, Fc-fusion constructs, tagged proteins and engineered variants tailored to your experimental needs.

Explore Custom Protein Production

Supporting Every Stage of Immune Checkpoint Research

Whether your objective is basic immunology research or therapeutic development, selecting the appropriate recombinant protein is essential for obtaining reliable experimental results.

Our products are routinely used for applications including:

- Receptor-ligand interaction studies
- Antibody screening and characterization
- ELISA development and validation
- Surface Plasmon Resonance (SPR)
- Bio-Layer Interferometry (BLI)
- Cell-based functional assays
- Flow cytometry assay development
- Biomarker validation
- Structural biology
- Immunotherapy target evaluation
- CAR-T and TCR research
- Drug discovery programs

FAQ

Many co-inhibitory and co-stimulatory receptors are glycoproteins that benefit from mammalian expression systems such as HEK293 or CHO cells. These systems help preserve native folding and post-translational modifications that are important for biological activity.

Trusted Worldwide

Why Researchers Trust ProteoGenix

From validated reagents for co-signaling receptor research to custom antibody development, recombinant production and technical support, ProteoGenix helps researchers move faster from target selection to reliable experimental results.

Scientific & Technical Support

Get expert support for product selection, format comparison, application fit and troubleshooting.
Quality Assurance

Work with documented reagents supported by QC processes and batch-specific information.
Custom Solutions

For specific targets or formats, ProteoGenix supports antibody development and recombinant production.
Global Delivery

Reliable cold-chain logistics worldwide with temperature-controlled shipping and tracking.

Co-inhibitory & Co-stimulatory receptors

Sudubrilimab Biosimilar - Research Grade mAb

Tamgiblimab Biosimilar - Anti-TIGIT mAb - Research Grade

Tazlestobart Biosimilar - Anti-CD152 mAb - Research Grade

Tebotelimab Biosimilar - Anti-PDCD1;LAG3 mAb - Research Grade

Tiragolumab Biosimilar - Anti-TIGIT, VSIG9, VSTM3 mAb - Research Grade

Tobemstomig Biosimilar - Anti-PD1 and LAG3 mAb - Research Grade

Tremelimumab Biosimilar - Anti-CTLA4, CD152 mAb - Research Grade

Tupaia chinensis CD152/CTLA4 Recombinant Protein, N-His

Tupaia chinensis CD274/PD-L1/B7-H1 Recombinant Protein, N-His

Tuparstobart Biosimilar - Anti-FDC mAb - Research Grade

Tuvonralimab Biosimilar - Anti-CTLA4 mAb - Research Grade

Vibostolimab Biosimilar - Anti-TIGIT, VSIG9, VSTM3 mAb - Research Grade

Vilastobart Biosimilar - Anti-CD152 mAb - Research Grade

Volrustomig Biosimilar - Anti-PD1 and CTLA4 mAb - Research Grade

Vudalimab Biosimilar - Anti-CTLA4;PDCD1 mAb - Research Grade

Xirestomig Biosimilar - Anti-Tumor necrosis factor receptor superfamily member 9; CD274 mAb - Research Grade

Top Products

Anti-Human TREM2 VHH (SAA1136)

Anti-Human CD354/TREM1 (PY159)

Anti-Mouse CD283/TLR3 Polyclonal Antibody

Human CD274/PD-L1/B7-H1 Monoclonal Antibody 2.7A4

Representative Immune Checkpoint Targets

Frequently studied co-inhibitory receptors

Frequently studied co-stimulatory receptors

Can’t find your target?

Supporting Every Stage of Immune Checkpoint Research

FAQ

Why Researchers Trust ProteoGenix

Scientific & Technical Support

Quality Assurance

Custom Solutions

Global Delivery

Need a quote or more information? Contact us!

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