What are co-inhibitory receptors?

Co-inhibitory receptors are immune cell surface proteins that transmit signals limiting immune activation. They help prevent excessive immune responses and support immune tolerance.

What are co-stimulatory receptors?

Co-stimulatory receptors provide activating signals that support T cell proliferation, survival and effector functions after antigen recognition.

Which targets are commonly studied?

Frequently studied targets include PD-1, PD-L1, CTLA-4, LAG-3, TIGIT, TIM-3, CD28, CD80, CD86, ICOS, OX40 and 4-1BB.

Which reagent format should I choose?

Choose primary antibodies for detection, recombinant proteins for binding or assay development, research-grade biosimilars for reference studies and VHH antibodies when a compact binder format is preferred.

What should I check before ordering?

Check the target name, species reactivity, clone, host, isotype, format, application, product size, storage conditions and stock availability.

Which expression system is recommended for immune checkpoint proteins?

Many co-inhibitory and co-stimulatory receptors are glycoproteins that benefit from mammalian expression systems such as HEK293 or CHO cells. These systems help preserve native folding and post-translational modifications that are important for biological activity.

Can ProteoGenix support custom requirements?

Yes. For targets or formats not available as standard products, ProteoGenix can support custom antibody development, recombinant antibody production and related services.

Co-inhibitory & Co-stimulatory receptors

Validated Reagents for Reliable Immune Checkpoint Research

Explore our validated range of primary antibodies, research-grade biosimilars and VHH antibodies targeting key co-inhibitory and co-stimulatory receptors, with products ready to ship.

Save 20% on this selection. Use code ONCO20. Valid until September 15

Ralzapastotug Biosimilar - Anti-VSTM3 mAb - Research Grade
- PX-TA2051
- Validated ELISA WB
Clonality:

Monoclonal Antibody

Isotype:

IgG1, kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $203.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Recombinant Cat CD274/PD-L1/B7-H1 Protein, N-His
- ARO-P10235
Host species:

Escherichia coli (E.coli)

Origin species:

Cat

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $356.00.Current price is: $274.00.
+ 274 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Recombinant Cat CD279/PDCD1/PD1 Protein, N-His
- ARO-P10236
Host species:

Escherichia coli (E.coli)

Origin species:

Cat

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $347.00.Current price is: $274.00.
+ 274 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Recombinant Human TIGIT, N-His
- ARO-P13316
Host species:

Escherichia coli (E.coli)

Origin species:

Human

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $337.00.Current price is: $274.00.
+ 274 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Recombinant Mouse TIGIT Protein, N-His
- ARO-P11061
Host species:

Escherichia coli (E.coli)

Origin species:

Mouse

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $331.00.Current price is: $274.00.
+ 274 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Relatlimab Biosimilar - Anti-LAG3, CD223 mAb - Research Grade
- PX-TA1496
Clonality:

Monoclonal Antibody

Isotype:

IgG4, Kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $203.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Renvistobart Biosimilar - Anti-VSTM3 mAb - Research Grade
- PX-TA1969
Clonality:

Monoclonal Antibody

Isotype:

IgG1, kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $230.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Reozalimab Biosimilar - Anti-PDCD1;CD274 mAb - Research Grade
- PX-TA1879
- Validated ELISA FC WB
Clonality:

Monoclonal Antibody

Isotype:

IgG1, kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $209.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Retlirafusp Biosimilar - Anti-CD274 mAb - Research Grade
- PX-TA1880
- Validated ELISA WB
Clonality:

Monoclonal Antibody

Isotype:

IgG4, Kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $207.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Rilvegostomig Biosimilar - Anti-PD-1 and TIGIT mAb - Research Grade
- PX-TA2078
Clonality:

Monoclonal Antibody

Isotype:

IgG1 Kappa, IgG1 Lambda

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $232.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Safimestomig Biosimilar - Research Grade
- PX-TA2453
Clonality:

Monoclonal antibody

Host species:

Mammalian cells

Isotype:

IgG4, Kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $203.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Solabafusp alfa Biosimilar - Research Grade
- PX-TA2417
Clonality:

Monoclonal antibody

Host species:

Mammalian cells

Isotype:

IgG4, Kappa fused lipocalin-2

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $212.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Sotiburafusp Alfa Biosimilar - Anti-B7-H1 fusion protein - Research Grade
- PX-TA1990
- Validated ELISA WB
Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $212.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Sovipostobart beta Biosimilar - Research Grade
- PX-TA2367
Clonality:

Monoclonal antibody

Host species:

Mammalian cells

Isotype:

IgG1, Kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $220.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Sovipostobart Biosimilar - Anti-CD152 mAb - Research Grade
- PX-TA1951
- Validated ELISA
Clonality:

Monoclonal Antibody

Isotype:

IgG1, kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $233.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Sudubrilimab Biosimilar - Anti-CD274 mAb - Research Grade
- PX-TA1717
Clonality:

Monoclonal Antibody

Isotype:

IgG1, kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: $200.00.Current price is: $167.00.
+ 167 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page

Co-inhibitory & Co-stimulatory Receptors

Researchers investigating immune regulation rely on co-inhibitory and co-stimulatory receptors to understand T cell activation, immune tolerance, cancer immunotherapy, autoimmune diseases, infectious diseases, and cell therapy development. Collectively, these molecules constitute the immune checkpoint pathways that regulate immune responses and have become central targets in immunology and immuno-oncology research.

ProteoGenix provides recombinant proteins and custom protein production services covering a broad range of immune checkpoint molecules and co-signaling receptors, supporting research from early discovery through preclinical development.

Representative Immune Checkpoint Targets

Immune checkpoint research encompasses a broad network of co-inhibitory and co-stimulatory receptors involved in regulating immune activation and tolerance. Below is a representative selection of targets available through ProteoGenix.

Frequently studied co-inhibitory receptors

Frequently studied co-stimulatory receptors

Can’t find your target?

Not all immune checkpoint molecules are commercially available in the format required for your study. Our scientists can design and produce custom recombinant proteins, antibodies, Fc-fusion constructs, tagged proteins and engineered variants tailored to your experimental needs.

Explore Custom Protein Production

Supporting Every Stage of Immune Checkpoint Research

Whether your objective is basic immunology research or therapeutic development, selecting the appropriate recombinant protein is essential for obtaining reliable experimental results.

Our products are routinely used for applications including:

- Receptor-ligand interaction studies
- Antibody screening and characterization
- ELISA development and validation
- Surface Plasmon Resonance (SPR)
- Bio-Layer Interferometry (BLI)
- Cell-based functional assays
- Flow cytometry assay development
- Biomarker validation
- Structural biology
- Immunotherapy target evaluation
- CAR-T and TCR research
- Drug discovery programs

FAQ

Many co-inhibitory and co-stimulatory receptors are glycoproteins that benefit from mammalian expression systems such as HEK293 or CHO cells. These systems help preserve native folding and post-translational modifications that are important for biological activity.

Trusted Worldwide

Why Researchers Trust ProteoGenix

From validated reagents for co-signaling receptor research to custom antibody development, recombinant production and technical support, ProteoGenix helps researchers move faster from target selection to reliable experimental results.

Scientific & Technical Support

Get expert support for product selection, format comparison, application fit and troubleshooting.
Quality Assurance

Work with documented reagents supported by QC processes and batch-specific information.
Custom Solutions

For specific targets or formats, ProteoGenix supports antibody development and recombinant production.
Global Delivery

Reliable cold-chain logistics worldwide with temperature-controlled shipping and tracking.

Co-inhibitory & Co-stimulatory receptors

Ralzapastotug Biosimilar - Anti-VSTM3 mAb - Research Grade

Recombinant Cat CD274/PD-L1/B7-H1 Protein, N-His

Recombinant Cat CD279/PDCD1/PD1 Protein, N-His

Recombinant Human TIGIT, N-His

Recombinant Mouse TIGIT Protein, N-His

Relatlimab Biosimilar - Anti-LAG3, CD223 mAb - Research Grade

Renvistobart Biosimilar - Anti-VSTM3 mAb - Research Grade

Reozalimab Biosimilar - Anti-PDCD1;CD274 mAb - Research Grade

Retlirafusp Biosimilar - Anti-CD274 mAb - Research Grade

Rilvegostomig Biosimilar - Anti-PD-1 and TIGIT mAb - Research Grade

Safimestomig Biosimilar - Research Grade

Solabafusp alfa Biosimilar - Research Grade

Sotiburafusp Alfa Biosimilar - Anti-B7-H1 fusion protein - Research Grade

Sovipostobart beta Biosimilar - Research Grade

Sovipostobart Biosimilar - Anti-CD152 mAb - Research Grade

Sudubrilimab Biosimilar - Anti-CD274 mAb - Research Grade

Top Products

Anti-Human TREM2 VHH (SAA1136)

Anti-Human CD354/TREM1 (PY159)

Anti-Mouse CD283/TLR3 Polyclonal Antibody

Human CD274/PD-L1/B7-H1 Monoclonal Antibody 2.7A4

Representative Immune Checkpoint Targets

Frequently studied co-inhibitory receptors

Frequently studied co-stimulatory receptors

Can’t find your target?

Supporting Every Stage of Immune Checkpoint Research

FAQ

Why Researchers Trust ProteoGenix

Scientific & Technical Support

Quality Assurance

Custom Solutions

Global Delivery

Need a quote or more information? Contact us!

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