CD66c Recombinant Protein

General information on CD66c Recombinant Protein:

The cell adhesion molecule associated with carcinoembryonic antigen 6 (non-specific cross-reactive antigen) (CEACAM6) is also known as CD66c (Cluster of Differentiation 66c), CEAL, NCA, and is one of the seven members of the human CEACAM family in the immunoglobulin superfamily. In humans, CEACAM includes type I transmembrane protein (CEACAM1, CEACAM3, and CEACAM4) and GPI-binding molecules (CEACAM5 to CEACAM8). There is no human CEACAM2. CEACAM 6 contains one N-terminal V-type Ig-like domain (N-domain), followed by two C2-like Ig-like domains. It shows considerable glycosylation, including LewisX (sialic acid), which mediates the binding of E-selectin, galectin, and certain bacterial fibers. CEACAM-6 is expressed by granulocytes and their precursors. It is also expressed in the epithelium of various organs and is regulated in adenocarcinomas of the pancreas and colon and hyperplastic polyps. In the case of overexpression of CEACAM6, it is resistant to adhesion-related apoptosis in tumor cells.