General Information about Interleukin-1 alpha (IL1)
The protein encoded by this gene is a member of the interleukin-1 cytokine family. This cytokine is a pleiotropic cytokine involved in a variety of immune responses, inflammatory processes and hematopoiesis. The cytokine is produced by monocytes and macrophages in the form of proprotein, which is proteolytically processed and released in response to cell damage, thereby inducing apoptosis. This gene and 8 other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been shown that these gene polymorphisms are related to rheumatoid arthritis and Alzheimer’s disease.
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