Recombinant Human ANXA7, N-His

Description of Recombinant Human ANXA7, N-His

Introduction

Recombinant Human ANXA7, N-His is a protein that has been genetically engineered for use in scientific research and potential therapeutic applications. This protein is a member of the annexin family, which are calcium-dependent phospholipid-binding proteins. ANXA7, also known as Annexin A7, plays a crucial role in regulating cellular processes such as membrane trafficking, cell signaling, and apoptosis. In this article, we will discuss the structure, activity, and potential applications of Recombinant Human ANXA7, N-His.

Structure of Recombinant Human ANXA7, N-His

The ANXA7 gene is located on chromosome 10 in humans and encodes for a protein of 505 amino acids. Recombinant Human ANXA7, N-His is produced by cloning the ANXA7 gene into a plasmid vector and expressing it in a suitable host cell, such as E. coli or mammalian cells. The resulting protein has a molecular weight of approximately 55 kDa and contains a polyhistidine (N-His) tag at the N-terminus, which allows for purification and detection of the protein.

ANXA7 has a unique structure consisting of four domains: a highly conserved core domain, an N-terminal domain, a C-terminal domain, and a linker region connecting the core and N-terminal domains. The core domain is responsible for calcium-dependent phospholipid binding, while the N-terminal and C-terminal domains are involved in protein-protein interactions. The linker region is important for regulating the conformational changes of ANXA7.

Activity of this protein

ANXA7 is a multifunctional protein that has been shown to play a role in various cellular processes. One of its main functions is as a calcium-dependent phospholipid binding protein, which allows it to interact with cell membranes and regulate membrane trafficking. ANXA7 has also been found to be involved in signal transduction pathways, such as the regulation of protein kinase C activity.

In addition, ANXA7 has been shown to play a role in apoptosis, or programmed cell death. It has been suggested that ANXA7 may act as a tumor suppressor by promoting cell death and inhibiting cell proliferation. Studies have also shown that ANXA7 may be involved in the development and progression of certain cancers, such as breast and prostate cancer.

Applications of Recombinant Human ANXA7, N-His

Due to its diverse functions, Recombinant Human ANXA7, N-His has potential applications in both research and therapeutics. In research, this protein can be used as a tool to study the role of ANXA7 in various cellular processes. Its recombinant form allows for easy purification and detection, making it a valuable tool in protein-protein interaction studies.

In terms of therapeutics, ANXA7 has been identified as a potential drug target for various diseases, including cancer and cardiovascular diseases. Recombinant Human ANXA7, N-His can be used to develop novel drugs that target ANXA7 and modulate its activity. Additionally, ANXA7 may also have potential as a biomarker for certain diseases, allowing for early detection and treatment.

Conclusion

Recombinant Human ANXA7, N-His is a genetically engineered protein that has a unique structure and diverse functions. Its role in regulating cellular processes and potential as a drug target make it a valuable tool in scientific research and a promising candidate for therapeutic applications. Further studies on ANXA7 and its recombinant form may lead to a better understanding of its functions and potential for disease treatment.