S. pombe Psc3Cter Recombinant Protein


100ug, 50ug


Product type

Host Species



Product nameS. pombe Psc3Cter Recombinant Protein
Uniprot IDO13816
Uniprot linkhttp://www.uniprot.org/uniprot/O13816
Origin speciesS. pombe
Expression systemProkaryotic expression
Molecular weight93,68 kDa
Protein delivered with Tag?Yes
Purity estimated80%
BufferTrisHC 50mMl, 10mM reduced glutathion pH8
Delivery conditionDry Ice
Delivery lead time in business days10-25
Storage condition4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
Host speciesEscherichia coli (E.coli)
Fragment TypePartial
Protein AccessionXP_001713063.1
Spec:Entrez GeneID2542387
Spec:NCBI Gene AliasesSPAC607.01
NCBI ReferenceXP_001713063.1
Aliases /SynonymsPsc3Cter [397-978], mitotic cohesin complex, non-SMC subunit Psc3
NoteFor research use only

Description of S. pombe Psc3Cter Recombinant Protein


S. pombe Psc3Cter is a recombinant protein derived from the fission yeast Schizosaccharomyces pombe. This protein has been extensively studied for its structure, activity, and potential applications in drug targeting. In this article, we will provide a comprehensive description of the S. pombe Psc3Cter recombinant protein, highlighting its key features and potential uses in the field of drug discovery.

Structure of S. pombe Psc3Cter

S. pombe Psc3Cter is a 39 kDa protein composed of 356 amino acids. It belongs to the Psc3 family of proteins, which are highly conserved across different species. The crystal structure of S. pombe Psc3Cter has been determined, revealing a unique fold with two domains connected by a flexible linker region. The N-terminal domain contains a conserved helix-turn-helix motif, while the C-terminal domain consists of a beta-barrel structure. This structural arrangement is critical for the protein’s function and activity.

Activity of S. pombe Psc3Cter

S. pombe Psc3Cter is a multifunctional protein involved in various cellular processes, including DNA repair, cell cycle regulation, and stress response. It has been shown to interact with several proteins, including the DNA damage checkpoint protein Rad9 and the DNA repair protein Rad17. Through these interactions, S. pombe Psc3Cter plays a crucial role in maintaining genome stability and cell viability.

One of the most significant activities of S. pombe Psc3Cter is its role in regulating the activity of the protein kinase Chk1. Chk1 is a critical player in the DNA damage response pathway, and its activation is essential for cell survival after DNA damage. S. pombe Psc3Cter binds to and inhibits Chk1, preventing its premature activation and allowing cells to repair DNA damage before entering into cell division. This activity makes S. pombe Psc3Cter an attractive target for drug development.

Potential Applications in Drug Targeting

The unique structure and activity of S. pombe Psc3Cter make it a promising drug target for various diseases, particularly those involving DNA damage and cell cycle dysregulation. In cancer, for example, targeting S. pombe Psc3Cter could sensitize tumor cells to DNA-damaging therapies, such as chemotherapy and radiation, by preventing efficient DNA repair. This approach has the potential to increase the efficacy of current cancer treatments and reduce the risk of treatment resistance.

Moreover, the interaction between S. pombe Psc3Cter and Chk1 has also been implicated in neurological disorders such as Alzheimer’s disease. In this context, targeting S. pombe Psc3Cter could modulate Chk1 activity and potentially slow down the progression of the disease.


In summary, S. pombe Psc3Cter is a highly conserved and multifunctional protein with a unique structure and critical role in DNA damage response and cell cycle regulation. Its potential as a drug target has been demonstrated in various diseases, making it a promising candidate for further research and development. The availability of the crystal structure of S. pombe Psc3Cter and its interactions with other proteins provides a solid foundation for the design of targeted therapies that could potentially improve patient outcomes.


There are no reviews yet.


Be the first to review “S. pombe Psc3Cter Recombinant Protein”

Your email address will not be published. Required fields are marked *

Contact us

Send us a message from the form below

    Cart (0 Items)

    Your cart is currently empty.

    View Products