Stable Isotope Labelled Evinacumab Biosimilar – Anti-ANGPTL3 mAb – Research Grade

Reference: PX-TA1369-SIL-1MG
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Applications

Product nameStable Isotope Labelled Evinacumab Biosimilar - Anti-ANGPTL3 mAb - Research Grade
SourceCAS 1446419-85-7
SpeciesHomo sapiens
Expression systemMammalian cells
Purity>95%
BufferPBS buffer PH7.5
Delivery conditionBlue Ice
Delivery Time3-5 days if in stock; 5-8 weeks if production needed
Storage conditionstore at -80°C
BrandProteoGenix
ApplicationsMS
Aliases /SynonymsREGN 1500
ReferencePX-TA1369-SIL
Related ProductsPX-P4695
NoteFor research use only. Not suitable for clinical or therapeutic use.
IsotypeIgG4-kappa
ClonalityMonoclonal Antibody
FormatLyophilized
LabellingArginine: 13C6,15N4 ; Lysine: 13C6,15N2, >99%
Isotopic Enrichment99%
Stability1 year

General information on Anti-ANGPTL3[Homo sapiens] (Evinacumab) Monoclonal Antibody

Evinacumab is a recombinant human IgG4 monoclonal antibody targeting human angiopoietin-like protein 3 (ANGPTL3). The ANGPTL protein family has many physiological functions-including the regulation of lipid metabolism. It has been noted that the loss-of-function mutation of ANGPTL3 leads to hypolipidemia and subsequently reduces cardiovascular risk, while increased function seems to be related to cardiovascular risk. Evinacumab has been used to treat homozygous familial hypercholesterolemia (HoFH). It has been sold under the Evkeeza brand name.

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