Question 1

Which developability parameters do you assess?

Accepted Answer

We assess key developability attributes such as stability (thermal/conformational), aggregation and self-association risk, solubility/formulation compatibility, charge-related heterogeneity (pI/variants), and sequence-based liabilities (e.g., deamidation/oxidation hotspots). Optional in silico immunogenicity risk screening can also be included.

Question 2

Is the assessment based on in silico predictions, experimental assays, or a combination of both?

Accepted Answer

We use a combination of both. AI-powered in silico predictions help us identify and prioritize the most relevant risks upfront, so we can design and optimize the experimental assays accordingly—focusing on the right parameters, faster, with less material.

Question 3

Can the assessment be performed on multiple antibody variants in parallel?

Accepted Answer

Yes — we can assess multiple antibody variants in parallel, enabling fast side-by-side comparison and selection of the most developable candidates.

Question 4

What analytical and biophysical methods are included?

Accepted Answer

Depending on your needs, the package can include Bradford or UV280 (concentration), SDS-PAGE (purity/integrity), ELISA (antigen binding), SEC-HPLC (purity/solubility/aggregation), DLS (size & aggregation), nanoDSF (thermostability), and SPR or BLI (affinity).

Question 5

What is the typical turnaround time?

Accepted Answer

Typical turnaround time is 2–3 weeks, depending on the number of variants and the selected assays.

Question 6

Can the service be adapted depending on molecule format (IgG, VHH, bispecifics)?

Accepted Answer

Yes — the assessment can be adapted to all antibody formats (e.g., IgG, VHH, bispecifics) and across species, with a methodology tailored to the specific molecule type.

Question 7

Do you provide clear go/no-go recommendations?

Accepted Answer

Yes — we deliver a detailed data report and provide clear go/no-go recommendations based on the results.

Question 8

Can the results guide subsequent optimization steps such as humanization or affinity maturation?

Accepted Answer

Yes — the results can be used to guide downstream optimization, including humanization service and affinity maturation services, by highlighting the key developability risks and priorities to address.

Question 9

Are your laboratories compliant with relevant quality standards (ISO, GMP-like)?

Accepted Answer

Yes — our laboratories operate under ISO-aligned quality standards, with GMP-like best practices applied where relevant to ensure robust traceability, documentation, and data integrity.

Question 10

Can you support downstream optimization if developability issues are identified?

Accepted Answer

Yes — if developability risks are identified, we can support downstream optimization, using AI-guided predictions to design and prioritize the most effective sequence and engineering strategies.

Question 11

Do you offer integrated packages combining discovery, engineering, and developability assessment?

Accepted Answer

Yes — we offer integrated end-to-end packages combining discovery, engineering, and developability assessment. Our teams work in synergy to support your program seamlessly from early candidate generation through final selection and optimization.

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