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ProteoGenix
Recombinant Proteins
Escherichia coli (E. coli)
Elisa, WB
Human TIVAMP is a human recombinant protein that has gained significant attention in the field of drug development due to its potential as a therapeutic target. This protein has been extensively studied for its structure, activity, and application, and has shown promising results in various disease models. In this article, we will discuss the key features of Human TIVAMP and its potential as a drug target.
Human TIVAMP is a transmembrane protein that is primarily expressed in the brain and spinal cord. It belongs to the family of voltage-gated ion channels and is composed of four subunits, each containing six transmembrane segments. The subunits are arranged in a tetrameric structure, forming a central pore that allows the passage of ions across the cell membrane.
The primary structure of Human TIVAMP is highly conserved among different species, indicating its crucial role in cellular function. However, its tertiary structure has been found to be dynamic, allowing for conformational changes that regulate its activity.
Human TIVAMP is a calcium channel that plays a crucial role in regulating intracellular calcium levels. It is activated by membrane depolarization, leading to the influx of calcium ions into the cell. This influx of calcium triggers various physiological processes such as neurotransmitter release, muscle contraction, and gene expression.
Studies have shown that dysregulation of Human TIVAMP activity is associated with various diseases, including epilepsy, migraine, and ataxia. Therefore, targeting this protein has become a promising approach for the treatment of these disorders.
As a drug target, Human TIVAMP has shown great potential in the treatment of neurological disorders. Several small molecule inhibitors have been developed to target this protein, with promising results in preclinical studies. These inhibitors have been found to effectively reduce the activity of Human TIVAMP, leading to a decrease in calcium influx and subsequent improvement in disease symptoms.
In addition to its role in neurological disorders, Human TIVAMP has also been implicated in cancer progression. It has been shown to promote tumor growth and metastasis by regulating calcium signaling pathways. Therefore, targeting this protein may also have potential applications in cancer treatment.
In summary, Human TIVAMP is a crucial protein involved in regulating intracellular calcium levels. Its dysregulation has been linked to various diseases, making it a promising drug target. The structure of Human TIVAMP, with its dynamic tertiary conformation, allows for the development of specific inhibitors that can effectively regulate its activity. With ongoing research and development, Human TIVAMP may hold the key to treating a wide range of diseases, making it an exciting area of study in the field of drug development.
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