Antibody-drug conjugates
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Antibody-drug conjugatesEverything you need to know about the generation of antibody-drug conjugates (ADCs)
Thomas Meyer
How to generate ADCs? Antibody-drug conjugates (ADCs) represent a powerful class of targeted cancer therapies that combine the specificity of monoclonal antibodies with the potency of cytotoxic drugs.
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Robust methods for the detailed analysis of drug-to-antibody ratio (DAR) and drug load distribution
What is the drug-to-antibody ratio, how is DAR distribution measured, and which DAR analysis methods are the most reliable? Average… Read More
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ADC linkers: Definition and examples
What are ADC linkers, what types of ADC linkers exist, and how do they affect payload release? ADC linkers, also… Read More
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Antibody Drug Conjugates (ADCs) in Cancer Therapy
In the relentless battle against cancer, researchers continually seek innovative strategies to enhance treatment efficacy while minimizing adverse… Read More
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The therapeutic potential of antibody-drug conjugates (ADCs)
To understand the therapeutic potential of antibody-drug conjugates (ADCs) it is essential to first analyze their mechanism of action,… Read More
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New and promising trends in therapeutic ADC generation
With the growth of the global market for therapeutic antibody-drug conjugates (ADCs), researchers are set on developing exciting new… Read More
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What are the most common targets for ADCs?
Currently, dozens of antibody-drug conjugates (ADCs) and immunotoxins have reached the clinic or are under active clinical development. These… Read More
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Therapeutic ADCs: mechanisms of action and advantages
The therapeutic value of antibody-drug conjugates (ADCs) is widely recognized as highly effective and safe for the treatment of… Read More
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Bioanalysis of antibody-drug conjugates (ADCs)
The bioanalysis of antibody-drug conjugates remains challenging. However, in recent years, many methodologies have been developed to tackle the… Read More
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Assessing the pharmacokinetics of antibody-drug conjugates (ADCs)
Pharmacokinetics (PK) and pharmacodynamics (PD) are two interdependent properties of ADCs. Together, they dictate the clinical outcomes of ADC… Read More
