Antibody-drug conjugates
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Antibody-drug conjugates
Antibody Drug Conjugates (ADCs) in Cancer Therapy
In the relentless battle against cancer, researchers continually seek innovative strategies to enhance treatment efficacy while minimizing adverse effects on healthy tissues. The development of novel therapies that…
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The therapeutic potential of antibody-drug conjugates (ADCs)
To understand the therapeutic potential of antibody-drug conjugates (ADCs) it is essential to first analyze their mechanism of action,… Read More
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New and promising trends in therapeutic ADC generation
With the growth of the global market for therapeutic antibody-drug conjugates (ADCs), researchers are set on developing exciting new… Read More
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What are the most common targets for ADCs?
Currently, dozens of antibody-drug conjugates (ADCs) and immunotoxins have reached the clinic or are under active clinical development. These… Read More
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Therapeutic ADCs: mechanisms of action and advantages
The therapeutic value of antibody-drug conjugates (ADCs) is widely recognized as highly effective and safe for the treatment of… Read More
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Bioanalysis of antibody-drug conjugates (ADCs)
The bioanalysis of antibody-drug conjugates remains challenging. However, in recent years, many methodologies have been developed to tackle the… Read More
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Assessing the pharmacokinetics of antibody-drug conjugates (ADCs)
Pharmacokinetics (PK) and pharmacodynamics (PD) are two interdependent properties of ADCs. Together, they dictate the clinical outcomes of ADC… Read More
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Key biochemical and biophysical properties of antibody-drug conjugates (ADCs)
Antibody-drug conjugates (ADCs) are complex molecules. Their key properties are heavily influenced by linker chemistry and antibody conjugation methods. For… Read More
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Robust methods for the detailed analysis of drug-to-antibody ratio (DAR) and drug load distribution
Average drug-to-antibody ratio (DAR) and drug load distribution are two vital properties of antibody-drug conjugates (ADCs). Over the years, several… Read More
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Everything you need to know about the generation of antibody-drug conjugates (ADCs)
Antibody-drug conjugates (ADCs) consist of three main elements: an antibody carrier, a cleavable or non-cleavable linker, and a bioactive… Read More